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torstai 20. lokakuuta 2016
Turmeric Extract May Prevent, Even Reverse Diabetes (Type 1 and 2)
Turmeric Extract May Prevent, Even Reverse Diabetes (Type 1 and 2)
As the pharmaceutically-driven medical paradigm continues to lose adherents
by the droves, and the public seeks a system that identifies and resolves the root causes of disease, interest is growing in the use of natural substances
and lifestyle modifications to prevent and treat blood sugar disorders.
And unlike a few decades ago, where most of the evidence for "natural healing"
was anecdotal, there are now thousands of studies on hundreds of natural substances
and therapeutic activities that may ameliorate blood sugar disorders and their
complications. You can check out a good portion of the relevant research on
the topic on GreenMedInfo.com's blood sugar disorder database.
Turmeric Extract May Reverse Pancreatic Damage In Type 1 Diabetes
It turns out that this spice may be a powerful therapeutic intervention for more
than just type 2 diabetics. Pre-clinical research now reveals it may have a role in
reversing pancreatic damage in insulin-dependent, type 1 diabetics, who are
routinely told that their condition can not be cured. Type 1 diabetics are rarely
educated to the fact that the root cause of their disorder can be addressed:
namely, that the deficiency and/or dysfunction of the beta cells in the pancreas
responsible for producing insulin can be repaired, as well as the autoimmune
issues at the heart of the problem.
Back in 2013, an exciting study published in the journal Diabetology & Metabolic Syndrometitled, "The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study),
"found that diabetic rats who received a novel water-soluble, high concentrate
(53.21%) curcumin derivative orally for 40 days showed an improvement of
their plasma glucose, insulin and C-peptide (a marker for the health and insulin
producing capability of the beta cells) levels, that began after about 4 months,
and continued to improve until the 10 month mark, when their values were almost
completely normalized and evidence of significant pancreatic regeneration could
be observed. The researchers concluded the novel curcumin derivative (NCD): "...possesses antidiabetic actions and enhanced pancreatic islets regeneration."
The daily dose used in this rodent study (80 mg/kg) was the body weight
equivalent of 6,400 mg or 6.4 grams of curcumin for an average North American
male adult (80 kilograms/176 lbs). Rodent and human physiology is, of course,
radically different, but significant crossovers nonetheless do exist. In another
article, titled "Why Turmeric May Be the Diseased Liver's Best Friend," we
reviewed research indicating that turmeric may help to reverse damage in and
even regenerate the diabetic liver, as well as safety literature on what is a safe
A 2001 study in cancer patients reported that quantities of curcumin up to
8 g, administered per day for three months, were not toxic and resulted in
significant anti-cancer properties in a number of those treated. Considering that turmeric is only 3-4% curcumin
by weight, this implies that a larger quantity of turmeric can be consumed
safely, as well.
Given that organ transplantation (pancreatic islet
transplants) is exceedingly expensive and prohibitive due to a lack of donor
material and the potential for rejection by the host, the notion that a safe,
affordable, and non-prescription spice extract like curcumin may have
significant therapeutic value and may even regenerate damaged pancreatic
tissue, is truly exciting. That said, it should be noted that since
curcumin is not patentable, it is unlikely the800 million dollars or more needed to fund the requisite
clinical trials needed to obtain FDA drug approval will materialize. Because the so-called "evidence" needed to
justify the use of a new treatment is locked behind an insurmountably high
paywall, don't count on randomized, controlled, trials being performed on this
"natural cure" in the near or distant future.
In this study, the authors surmised that the
ameliorative effects curcumin treatment on type 1 diabetic rodents observed
were the result of beta cell regeneration and they explained the theory behind
how this works:
Each tissue or organ is believed to contain a small
sub-population of cells that is capable of self-renewal and has the ability to
give rise to each mature cell type .
Thus, one of the most promising sources of beta cells might be pancreatic stem
The researchers theorized that curcumin likely
"...a favorable systemic and pancreatic
environment to foster bone marrow transplantation and islet neogenesis.
Accordingly, administration of curcumin; as an established anti-inflammatory
and immune modulatory drug; would likely boost and preserve the process of
islet regeneration; which was evidently proven true in this study."
Curcumin's "immunomodulatory" benefit in
type 1 diabetes, also known as autoimmune diabetes, appears to be based on it
reducing the activity of the host immune system in attacking self-structures.
In fact, another recent study, published in 2014 in the journalClinical and Experimental Immunology titled,
"Curcumin ameliorates autoimmune diabetes. Evidence in
accelerated murine models of type 1 diabetes," found that curcumin down-regulates the T cell
response that destroys pancreatic beta cells, resulting in an improvement in
autoimmune or type 1 diabetes.
It is important for the reader to know that curcumin
is not a magic bullet; nor is it the only natural substance studied to have
potential beta cell regenerative properties. Indeed, pancreatic regeneration
has been induced experimentally for at least 23 different natural substances.
We have a keyword dedicated to indexing relevant research on the topic here:beta cell
highlighted 10 of the most compelling ones in our article, "10 Natuaral
Substances That Could Help Cure Type 1 Diabetes."
the research continues to accumulate on the value of natural substances for
disease prevention and treatment, it is clear the future of medicine will rely
on returning to the wisdom of the ancients, where Hippocrates' fundamental
principle that one can "cure the patient with food" is once again