tiistai 31. maaliskuuta 2020

Doctor’s claims of 100% success treating 699 Cov-19 patients are questioned


  • Chloroquine phosphate, an old-fashioned anti-malarial drug, has shown strong results against COVID-19 infections.
  • According to South Korean and China human treatment guidelines, chloroquine is effective in treating COVID-19.
  • Zinc appears to be the most effective agent in disrupting the virus and preventing the ‘cytokine storm’
  • In the 2019–20 coronavirus pandemic, a number of deaths due to COVID-19 have been attributable to cytokine release storms.
 

Doctor’s claims of 100% success treating 699 Cov-19 patients are questioned


By M. Dowling | March 31, 202



Dr. Vladimir Zelenko, a general practitioner who treats patients in a Hassidic community, claims to have successfully treated 699 coronavirus patients with success — no deaths and only four hospitalizations.

The doctor used the Hydroxy Chloroquine, Azithromycin and Zinc cocktail. Hitting the virus early and hard, as soon as symptoms appear, is key he claims. By the time the patients are intubated, it’s usually too late.
He shared the results with Rudy Giuliani @RudyGiuliani.

The former New York City mayor also reproduced the results of French virologist Didier Raoult’s study of 80 patients with the cocktail.

The Washington Post reported on Thursday that Dr. Vladimir Zelenko, who discussed his use of the drug in combination with antibiotics in a Forward article on Tuesday, had been contacted by President Trump’s new chief of staff, Rep. Mark Meadows. A person close to Meadows told the Post that the two had been in touch and White House experts were evaluating Zelenko’s protocol.
Reports also said that Vice President Mike Pence has urged the Food and Drug Administration (FDA) to expedite the bureaucratic process so that Dr. Zelenko’s medicine, which also includes antibiotics, zinc, vitamins, and anti-fever medication, will be available for use with coronavirus patients.

IT COULD BE FRAUDULENT

Meanwhile, leaders and community groups in Dr. Zelenko’s hometown of Kiryas Joel have requested he cease publicizing his new medication, or else leave them out of his statements after he wrongly claimed that 90% of the town’s population had coronavirus. The county health commissioner blasted the statement as “irresponsible” in light of the fact that he had only tested 14 patients.
Dr. Zelenko works in a clinic near the Hassidic community, Kiryas Joel.
It seems this would be an easy thing to verify. The difference between hundreds and fourteen patients is rather significant.
Mr. Giuliani, Charlie Kirk, and Laura Ingraham had their tweets promoting the drugs taken down.
Watch:

https://youtu.be/1TJdjhd_XG8 
https://www.independentsentinel.com/doctors-claims-of-100-success-treating-699-cov-19-patients-are-questioned/


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Studies Claim Malaria Drug Chloroquine Effective Against Coronavirus

  • Chloroquine phosphate, an old-fashioned anti-malarial drug, has shown strong results against COVID-19 infections.
  • According to South Korean and China human treatment guidelines, chloroquine is effective in treating COVID-19.
  • Zinc appears to be the most effective agent in disrupting the virus and preventing the ‘cytokine storm’
  • In the 2019–20 coronavirus pandemic, a number of deaths due to COVID-19 have been attributable to cytokine release storms.









Sure this Coronavirus pandemic is a misery but I’m much 
more optimistic than most at the moment. Here’s one of the reasons: there’s an effective treatment already and it’s available and cheap, according to studies.
Chloroquine phosphate, an old-fashioned anti-malarial drug, has shown strong results against COVID-19 infections in South Korea and China.
As Anthony Watts notes here there have been at least three studies demonstrating its efficacy against the Coronavirus.

Here is one, by James M Todaro and Gregory J Rigano:
According to the summary:
Recent guidelines from South Korea and China report that chloroquine is an effective antiviral therapeutic treatment against Coronavirus Disease 2019.  Use of chloroquine (tablets) is showing favorable outcomes in humans infected with Coronavirus including faster time to recovery and shorter hospital stay.  US CDC research shows that chloroquine also has strong potential as a prophylactic (preventative) measure against coronavirus in the lab, while we wait for a vaccine to be developed.  Chloroquine is an inexpensive, globally available drug that has been in widespread human use since 1945 against malaria, autoimmune and various other conditions.
It concludes:
Chloroquine can both prevent and treat malaria.  Chloroquine can both prevent and treat coronavirus in primate cells (Figure 1 and Figure 2).  According to South Korean and China human treatment guidelines, chloroquine is effective in treating COVID-19.  Given chloroquine’s human safety profile and existence, it can be implemented today in the U.S., Europe and the rest of the world.  Medical doctors may be reluctant to prescribe chloroquine to treat COVID-19 since it is not FDA approved for this use.  The United States of America and other countries should immediately authorize and indemnify medical doctors for prescribing chloroquine to treat COVID-19.  We must explore whether chloroquine can safely serve as a preventative measure prior to infection of COVID-19 to stop further spread of this highly contagious virus.
Here is the second study by Jianjun Gao, Zhenxue Tian, Xu Yang
Abstract:
The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People’s Republic of China for treatment of COVID-19 infection in larger populations in the future.

Here is the third, in the journal Nature
It’s titled ‘Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro’

Extract:
Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demonstrated that chloroquine functioned at both entry, and at post-entry stages of the 2019-nCoV infection in Vero E6 cells (Fig. 1c, d). Besides its antiviral activity, chloroquine has an immune-modulating activity, which may synergistically enhance its antiviral effect in vivo. Chloroquine is widely distributed in the whole body, including lung, after oral administration. The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90 μM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500 mg administration.11 Chloroquine is a cheap and a safe drug that has been used for more than 70 years and, therefore, it is potentially clinically applicable against the 2019-nCoV.

What does this mean?
Essentially it means the end of the nightmare is – or ought to be – much closer than we think.
It will take many, many months before a vaccine is available for COVID-19. In the meantime, this is a very effective stop-gap solution. Not only does it make those critically affected by the virus less likely to die; but it also acts as a prophylactic – that is, it is capable of stopping people from getting the disease in the first place.

The reason that Chloroquine works, I understand from an expert

in viral pandemics, is that enables the body to absorb more zinc.
Zinc appears to be the most effective agent in disrupting the virus and preventing the cytokine storm, which is the deadly phase in which the virus tricks the body’s immune system into attacking its own healthy tissue, with often fatal consequences.


Cytokine release syndrome


Cytokine release syndrome
 (CRS) is a form of systemic inflammatory response syndrome that can be triggered by a variety of factors such as infections and certain drugs.[3] It occurs when large numbers of white blood cells are activated and release inflammatory cytokines, which in turn activate yet more white blood cells. CRS is also an adverse effect of some monoclonal antibody drugs, as well as adoptive T-cell therapies.[4][5] Severe cases have been called cytokine storms.[2] When occurring as a result of drug administration, it is also known as an infusion reaction.[1]


CRS is a form of systemic inflammatory response syndrome and is an adverse effect of some drugs.[4]


The first reference to the term cytokine storm in the published medical literature appears to be by Ferrara et al. in 1993 in a discussion of graft vs. host disease; a condition in which the role of excessive and self-perpetuating cytokine release had already been under discussion for many years.[14][15] The term next appeared in a discussion of pancreatitis in 2002, and in 2003 it was first used in reference to a reaction to an infection.[14]
It is believed that cytokine storms were responsible for the disproportionate number of healthy young adult deaths during the 1918 influenza pandemic, which killed 50 to 100 million people.[16] In this case, a healthy immune system may have been a liability rather than an asset. Preliminary research results from Taiwan also indicated this as the probable reason for many deaths during the SARS epidemic in 2003.[17] Human deaths from the bird flu H5N1 usually involve cytokine storms as well.[18] Cytokine storm has also been implicated in hantavirus pulmonary syndrome.[19]
In 2006, a medical study at Northwick Park Hospital in England resulted in all 6 of the volunteers given the drug TGN1412 becoming critically ill, with multiple organ failure, high fever, and a systemic inflammatory response.[20] Parexel, a company conducting trials for pharmaceutical companies, in one of its own documents, wrote about the trial and said TGN1412 could cause a cytokine storm—the dangerous reaction the men experienced.[21]

In the 2019–20 coronavirus pandemic, a number of deaths due to COVID-19 have been attributable to cytokine release storms.[22][23][24]



Why isn’t there more excitement about this readily available treatment?
One possible reason is that chloroquine is a generic drug to which no pharmaceutical company owns the patent. Big Pharma’s money and lobbying power will strive to persuade governments – and markets – that the only viable solution to the coronavirus is a vaccine. But in the short term this simply isn’t true. Nor is it clear to me that the global economy is going to survive on lockdown for as long as it takes to develop and test that vaccine – which may not even prove effective in any case.
Note that point in the Todaro and Rigano paper about the need for FDA approval. There is no time to waste.
Medical staff shows on February 26, 2020 at the IHU Mediterranee Infection Institute in Marseille, packets of a Nivaquine, tablets containing chloroquine and Plaqueril, tablets containing hydroxychloroquine, drugs that has shown signs of effectiveness against coronavirus. - The Mediterranee infection Institute in Marseille based in La Timone Hospital is at the forefront of the prevention against coronavirus in France. (Photo by GERARD JULIEN / AFP) (Photo by GERARD JULIEN/AFP via Getty Images)
Medical staff shows at the IHU Mediterranee Infection Institute in Marseille, packets of a Nivaquine, tablets containing chloroquine and Plaqueril, tablets containing hydroxychloroquine, drugs that has shown signs of effectiveness against coronavirus. 
– The Mediterranee infection Institute in Marseille based in La Timone Hospital is at the forefront of the prevention against coronavirus in France. 
UPDATE: The Stanford University School of Medicine and National Academy of Sciences Researchers told the Huffington Post that they were not associated with the study conducted by James Todaro and Gregory Rigano. This story has been edited to reflect that.

HealthLondon / EuropePoliticsbig pharmaChloroquinecoronavirusCOVID-19Malaria





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 2020 Mar 16;14(1):72-73. doi: 10.5582/bst.2020.01047. Epub 2020 Feb 19.

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.

Abstract

The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.

KEYWORDS:

2019-nCoV; COVID-19; SARS-CoV-2; chloroquine; pneumonia
PMID:
 
32074550
DOI: 10.5582/bst.2020.01047
[Indexed for MEDLINE] 
Free full text

https://www.ncbi.nlm.nih.gov/pubmed/32074550


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perjantai 20. maaliskuuta 2020

Indian Scientists Discover Coronavirus Engineered With HIV (AIDS) Like Insertions

  • The study found 4 new AIDS like insertions in the Coronavirus which were absent from other Coronaviruses.
  • This finding the study states is “unlikely to be fortuitous in nature”, meaning that it is not a naturally occurring phenomenon.



Indian Scientists Discover Coronavirus Engineered With HIV (AIDS) Like Insertions




By GreatGameIndia

February 1, 2020| Last modified on February 29th, 2020 at 9:37 pm,





Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
A group of Indian scientists have discovered that Wuhan Coronavirus has been engineered with AIDS like insertions. The study concludes that it is unlikely for a virus to have acquired such unique insertions naturally in a short duration of time. Meanwhile, China has started using AIDS drug for Coronavirus treatment.
Note: Authors of “uncanny” 2019-nCoV preprint have voluntarily withdrawn the preprint: “It was not our intention to feed into the conspiracy theories…we appreciate the criticisms… and will get back with a revised version”
Indian Scientists Discover Coronavirus Engineered With AIDS Like Insertions.
The study was undertaken by scientists from Indian Institute of Technology, Acharya Narendra Dev College and University of Delhi and has been published under the title Uncanny similarity of novel inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag.
The study found 4 new AIDS like insertions in the Coronavirus which were absent from other Coronaviruses. This finding the study states is “unlikely to be fortuitous in nature”, meaning that it is not a naturally occurring phenomenon.
We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019-nCoV). The evolution of 2019-nCoV remains elusive. We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all the 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-1 Gag.


Modelled homo-trimer spike glycoprotein of 2019-nCoV virus
Modelled homo-trimer spike glycoprotein of 2019-nCoV virus. The inserts from HIV envelop protein are shown with colored beads, present at the binding site of the protein.

Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site. The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature. This work provides yet unknown insights on 2019-nCoV and sheds light on the evolution and pathogenicity of this virus with important implications for diagnosis of this virus.
The scientists were surprised to observe such insertions and were startled “as it is quite unlikely for a virus to have acquired such unique insertions naturally in a short duration of time”.
India in Cognitive Dissonance Book by GreatGameIndia
Since the S protein of 2019-nCoV shares closest ancestry with SARS GZ02, the sequence coding for spike proteins of these two viruses were compared using MultiAlin software. We found four new insertions in the protein of 2019-nCoV- “GTNGTKR” (IS1), “HKNNKS” (IS2), “GDSSSG” (IS3) and “QTNSPRRA” (IS4).


Multiple sequence alignment between spike proteins of 2019-nCoV and SARS
Multiple sequence alignment between spike proteins of 2019-nCoV and SARSFigure 2: Multiple sequence alignment between spike proteins of 2019-nCoV and SARS. The sequences of spike proteins of 2019-nCoV (Wuhan-HU-1, Accession NC_045512) and of SARS CoV (GZ02, Accession AY390556) were aligned using MultiAlin software. The sites of difference are highlighted in boxes.

To our surprise, these sequence insertions were not only absent in S protein of SARS but were also not observed in any other member of the Coronaviridae family (Supplementary figure). This is startling as it is quite unlikely for a virus to have acquired such unique insertions naturally in a short duration of time.
The study concludes that it is because of these 4 new AIDS like insertions that Wuhan Coronavirus has jumped to humans originally known only to infect animals.
These proteins are critical for the viruses to identify and latch on to their host cells and for viral assembly. Since surface proteins are responsible for host tropism, changes in these proteins imply a change in host specificity of the virus. According to reports from China, there has been a gain of host specificity in case 2019-nCoV as the virus was originally known to infect animals and not humans but after the mutations, it has gained tropism to humans as well.
The study gives credence to GreatGameIndia‘s earlier reports on Coronavirus Bioweapon. Meanwhile, China has started using AIDS drugs for Coronavirus treatment. China is using AbbVie Inc’s HIV drugs as an ad-hoc treatment for pneumonia caused by the novel coronavirus while the global search for a cure continues.
The Beijing branch of China’s National Health Commission said that a combination of lopinavir and ritonavir, sold under the brand name Kaletra by AbbVie, is part of its latest treatment plan for patients infected by the virus, which has killed at least 56 people in China and sickened more than 2,000 worldwide.
The NHC said that while there is not yet any effective anti-viral drug, it recommends patients are given two lopinavir and ritonavir tablets twice a day and a dose of alpha-interpheron through nebulization twice daily.
Medical journal Lancet said on Friday that a clinical trial is under way using ritonavir and lopinavir to treat cases of the new coronavirus. Meanwhile, China’s Center for Disease Control and Prevention will start developing a vaccine, according to the Global Times.
Wang Guangfa, a respiratory expert at Peking University First Hospital in Beijing who was infected by the virus after visiting Wuhan to inspect to coronavirus patients, told China News Week earlier this week that his doctor recommended he take the HIV drugs to fight the new virus and they worked on him.

https://greatgameindia.com/indian-scientists-discover-coronavirus-engineered-with-aids-like-insertions/

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