maanantai 26. tammikuuta 2015

THE STOMACH DOES NOT DIGEST FOOD, IT ALKALIZES FOOD!







The following scientific discourse are twenty-five important points to understand concerning the creation of sodium bicarbonate (NaHCO3) and hydrochloric acid (HCL) in the stomach lining, the ingestion of protein, cheese and sugar in any form and how acid/alkaline biochemistry, physiology, and anatomy relate to health, sickness, and disease.











How is acid/base created in the body?Unfortunately, contemporary medical doctors and scientists as well as alternative health practitioners do not understand how acid/base are created in the body and the onset of latent tissue acidosis in the colloidal connective tissue or the “Schade”. 


Welcome to the 21st century and Dr. Young’s “New Biology.”


1) The parietal or cover cells of the stomach split the sodium chloride (NaCl) of the blood. The sodium is used to bind with water and carbon dioxide to form the alkaline salt, sodium bicarbonate or NaHCO3. 

The biochemistry is:
H20 + CO2 + NaCl = NaHCO3 + HCL.

This is why a call the stomach an alkalizing organ NOT an organ of digestion.
The stomach DOES NOT digest the food or liquids you ingest it alkalizes the food and liquid you ingest.


2) For each molecule of sodium bicarbonate (NaHCO3) made, a molecule of hydrochloric acid (HCL) is made and secreted into the so-called digestive system – specifically, the stomach (the gastric pits in the stomach) – to be eliminated. Therefore HCL is an acidic waste product of sodium bicarbonate created by the stomach to alkalize the food and liquids ingested.





3) The chloride ion from the sodium chloride (salt) binds to an acid or proton forming HCL as a waste product of sodium bicarbonate production. HCL has a pH of 1 and is highly toxic to the body and the cause of indigestion, acid reflux, ulcers and cancer.

4) When large amounts of acids, including HCL, enter the stomach from a rich animal protein or dairy product meal, such as meat and cheese, acid is withdrawn from the acid-base household. The organism would die if the resulting alkalosis – or NaHCO3 (base flood) or base surplus – created by the stomach was not taken up by the alkalophile glands that need these quick bases in order to build up their strong sodium bicarbonate secretions. These glands and organs are the stomach, pancreas, Brunner’s glands (between the pylorus and the junctions of the bile and pancreatic ducts), Lieberkuhn’s glands in the liver and its bile with its strong acid binding capabilities which it has to release on the highly acidic meat and cheese to buffer its strong acids of nitric, sulphuric, phosphoric, uric and lactic acids.

5) When a rich animal protein and dairy product meal is ingested, the stomach begins to manufacture and secrete sodium bicarbonate (NHCO3) to alkalize the acids from the food ingested. This causes a loss in the alkaline reserves and an increase in acid and/or HCL found in the gastric pits of the stomach. These acids and/or HCL are taken up by the blood which lowers blood plasma pH. The blood eliminates this increase in gastrointestinal acid by throwing it off into the Pishinger’s spaces.

6) The space enclosed by these finer and finer fibers is called the Pishinger’s space, or the extracellular space that contains the fluids that bath and feed each and every cell while carrying away the acidic waste from those same cells. There is no mention of this organ in American physiology text books. There is mention of the extracellular space but not of any organ that stores acids from metabolism and diet, like the kidney. I call this organ the “pre-kidney” because it stores metabolic and gastrointestinal acids until they can be buffered and eliminated via the skin, urinary tract, or bowels.

7) After a rich animal protein or dairy product meal, the urine pH becomes alkaline. The ingestion of meat and cheese causes a reaction in acidic fashion in the organism by the production of sulfuric, phosporhoric, nitric, uric, lactic, acetylaldehyde and ethanol acids, respectively, but also through the formation and excretion of base in the urine. Therefore eating meat and cheese causes a double loss of bases leading to tissue acidosis and eventual disease, especially inflammation and degenerative diseases.

8) During heavy exercise, if the the resulting lactic acid was not adsorbed by the collagen fibers, the specific acid catchers of the body, the organism would die. The total collection of these fibers is the largest organ of the body called SCHADE, the colloidal connective tissue organ. NO liquid exchange occurs between the blood and the parenchyma cells, or in reverse, unless it passes through this connective tissue organ. This organ connects and holds everything in our bodies in place. This organ is composed of ligaments, tendons, sinew, and the finer fibers that become the scaffolding that holds every single cell in our bodies in place. When acids are stored in this organ, which includes the muscles, inflammation and pain develop. The production of lactic acid is increased with the ingestion of milk, cheese, yogurt, butter and especially ice cream.
That is why I have stated, “acid is pain and pain is acid.” You cannot have one without the other. This is the beginning of latent tissue acidosis leading to irritation, inflammation and degeneration of the cells, tissues and organs.

9) The more acidity created from eating meat, cheese, milk or ice cream the more gastrointestinal acids are adsorbed into the the collagen fibers to be neutralized and the less sodium bicarbonate or NaHCO3 that is taken up by the alkalophile glands. The larger the potential difference between the adsorbed acids and the amount of NaHCO3 generated with each meal, the more or less alkaline are the alkalophile glands like the pancreas, gallbladder, pylorus glands, blood, etc. The acid binding power of the connective tissue, the blood, and the alkalophile glands depends on its alkali reserve, which can be determined through blood, urine, and saliva pH, including live and dried blood analysis as taught by Dr. Robert O. Young. The saliva pH is an indication of alkali reserves in the alkalophile glands and the urine pH is an indication of the pH of the fluids that surround the cells or the Pishinger’s space.

10) The iso-structure of the blood maintains the pH of the blood by pushing off gastrointestinal or metabolic acids into the connective tissue or the Pishinger’s space. The blood gives to the urine the same amount of acid that it receives from the tissues and liver so it can retain its iso-form. A base deficiency is always related to the deterioration of the deposit ability of the connective tissues or the Pishinger’s space. As long as the iso-structure of the blood is maintained, the urine – which originates from the blood – remains a faithful reflected image of the acid-base regulation, not of the blood, but of the tissues. The urine therefore is an excretion product of the tissues, not the blood.
So when you are testing the pH of the urine, you are testing the pH of the tissues.


11) A latent “acidosis” is the condition that exists when there are not enough bases in the alkalophile glands because they have been used up in the process of neutralizing the acids adsorbed to the collagen fibers. This leads to compensated “acidosis.” This means the blood pH has not changed but other body systems have changed. This can then lead to decompensated “acidosis” where the alkaline reserves of the blood are used up and the pH of the blood is altered. Decompensated “acidosis” can be determined by testing the blood pH, urine pH and the saliva pH. The decrease in the alkaline reserves in the body occurs because of hyper-proteinization, (eating Meat and Cheese!)or too much protein, and hyper-carbonization, or too much sugar. This is why 80 to 90 year old folks are all shrunk up and look like prunes. They have very little or no alkaline reserves in their alkalophile glands. When all the alkaline minerals are gone, so are you and your battery runs down. The charge of your cellular battery can be measured by testing the ORP or the oxidative reduction potential of the blood, urine or saliva using an ORP meter. As you become more acidic this energy potential or ORP increases.

12) If there is not enough base left over after meat and cheese or surgary meal, or enough base to neutralize and clear the acids stored in the connective tissues, a relative base deficiency develops which leads to latent tissue acidosis. When this happens the liver and pancreas are deficient of adequate alkaline juices to ensure proper alkalization of the food in your stomach and small intestine.

13) Digestion or alkalization cannot proceed without enough of these alkaline juices for the liver and pancreas, etc., and so the stomach has to produce more acid in order to make enough base, ad nauseam, and one can develop indigestion, nausea, acid reflux, GERD, ulcers, esophageal cancer and stomach cancer. All of these symptoms are not the result of too much acid or HCL in the stomach. On the contrary, it is the result of too little base in the form of sodium bicarbonate!
14) Therefore the stomach is NOT an organ of digestion as currently taught in ALL biology and medical texts, BUT an organ of contribution or deposit. It’s function is to deposit alkaline juices to the stomach to alkalize the food and to the blood to carry to the alklophile glands!!!!

15) There is a daily rhythm to this acid base ebb and flow of the fluids of the body. The stored acids are mobilized from the connective tissues and Pishinger’s spaces while we sleep.
These acids reach their maximum (base tide) concentration in this fluid, and thereby the urine (around 2 a.m. is the most acidic). The acid content of the urine directly reflects the acid content of the fluid in the Pishinger’s spaces, the extracellular fluid compartments of the body. On the other hand, the Pishinger’s spaces become most alkaline around 2 p.m. (the base flood) as then the most sodium bicarbonate (NaHCO3) is being generated by the cover cells of the stomach to alkalize the food and drink we have ingested.

16) If your urine is not alkaline by 2 p.m. you are definitely in an ACIDIC condition and lacking in alkaline reserves. The pH of the urine should run between 6.8 and 8.4 but ideally 7.2 or greater.

17) After a high protein meal or meat or cheese, the free acids formed such as sulfuric, phosphoric, uric, and nitric acids stick to the collagen fibers to remove them from the blood and protect the delicate pH of the blood at 7.365. The H+ or proton ions from these acids are neutralized by the next base flood, the sodium bicarbonate produced after the meal. The H+ or proton ion combines with the carbonate or HCO3, converts to carbonic acid, H2CO3, which converts to CO2 and H2O. The sulfuric and other acids from proteins are neutralized as follows where the HR represents any acid with the R as its acid radical (SO4, PO4, or NO3) HR + NaHCO3 H2O + NaR (Ca, Mg, K)+ CO2.

18) Medical doctors and savants are not taught in medical school and therefore do not understand or recognize latent tissue acidosis. They understand and recognize compensated acidosis and decompensated acidosis. In compensated acidosis, breathing increases in order to blow off more carbonic acid which decreases PCO2 because of the lowered carbonate or HCO3. When the breathing rate can no longer get any faster and when the kidneys can no longer increase its’ function to keep up with the acid load, then the blood pH starts to change from a pH of 7.365 to 7.3 then to 7.2. At a blood pH of 6.95 the heart relaxes and the client goes into a coma or dies.

19) Metabolism of a normal adult diet results in the generation of 50 to 100 meq of H+ or proton per day, which must be excreted if the urine acid-base balance is to be maintained. A meq is a milliequivalent which is an expression of concentration of substance per liter of solution, calculated by dividing the concentration in milligrams per 100 milliliters by the molecular weight. This process involves two basis steps;
1) the reabsorption of the filtered sodium bicarbonate or NaHCO3 and,
2) excretion of the 50 to 100 meq of H+ or proton produced each day by the formation of titratable acidity and NH4+ or ammonium.
Both steps involve H+ or proton secretion from the cells of the kidney into the urine.


20) Sodium bicarbonate (NaHCO3) must be reabsorbed into the blood stream, since the loss of NaHCO3 will increase the net acid load and lower the plasma NaHCO3 concentration. The loss of NaHCO3 in the urine is equivalent to the addition of H+ to the body since both are derived from the dissociation of H2CO3 or carbonic acid.

21) The biochemistry is: CO2 + H2O = H2CO3 = HCO3 + H+. The normal subject must reabsorb 4300 meq of NaHCO3 each day! The secreted H+ or proton ions are generated within the kidney cells from the dissociation of H2O or water. This process also results in the equimolar production OH- or hydroxyl ions. The OH- ions bind to the active zinc-containing site of the intracellular carbonic anhydrase; they then combine with CO2 to form HCO3- ions which are released back into the kidney cells and returned to the systemic circulation. Second, the dietary acid load is excreted by the secretion of H+ or proton ions from the kidney cells into the urine. These H+ or proton ions can do one of two things: the H+ or proton ions can be combined with the urinary buffers, particularly HPO4, in a process called titratable acidity (The biochemistry is: H+ + HPO4 = H2PO4), or the phosphate buffering system or the H+ or proton ions can combine with ammonia (NH3) to form ammonium as follows: NH3 + H+ = NH4.
22) This ammonia is trapped and concentrated in the kidney as ammonium which is then excreted in the urine.

23) In response to acid load, 36% of the H+ or proton goes intracellular in exchange for the release of Na+ (sodium) into the blood stream. 15% of the acid goes intracellular in exchange for K+ (potassium) – common in diabetics. 6% of the H+ or proton or acid goes directly into the cell to be buffered by intracellular processes. 43% is buffered extracellularly as NaHCO3- or sodium bicarbonate combining with H+ or proton to form H2CO3 or carbonic acid which breaks down to CO2 or carbon dioxide to be released by the lungs. 10% of CO2 or carbon dioxide is excreted through the lungs and 90% is used by the body to reabsorb alkaline minerals and make sodium bicarbonate for buffering gastrointestinal and metabolic acids.
The biochemistry is: CO2 + H2O = H2CO3 = HCO3 + H+.


24) Of all the ways the body can buffer metabolic and dietary acids, the excretion of protein (the eating of meat and cheese) generated acid residues is the only process that does not add sodium bicarbonate back into blood circulation. This creates a loss of bases which is the forerunner of all sickness and disease. In the long run, the only way to replace these lost bases is by eating more alkaline electron-rich green foods and long-chain polyunsaturated fats. Eating meat and cheese is definitely hazardous to your health. That is why I say, “a cucumber a day keeps the doctor away while eating meat, cheese and even an apple creates more excess acid in the colloidal connective tissues, leading to latent tissue acidosis.
25) With over 30 years of research and testing over 500,000 samples of blood and over 1,000,000 samples of urine and saliva I have come to the conclusion that the Human Body is an acid producing organism by function – yet, it is an alkaline organism by design. Eating animal protein, especially meat and cheese and sugar from any source are deadly acidic choices – unless you interested in becoming sick, tired and fat over time.
Bottom line – the pH Miracle Lifestyle and Diet is a program that focuses on the foundational principal that the body is alkaline by design and yet acidic by function.
This make this program the ultimate program for preventing and reversing aging and the onset of sickness and dis-ease. I would say that the pH Miracle Lifestyle and Diet is the diet for a longer healthier life.

Please remember this very important truth, hydrochloric acid is not the cause of digestion but the result of digestion.

Start alkalizing today and begin improving the quality and quantity of your life today.


http://www.phoreveryoung.com, www.phmiracleliving.com

http://graviolateam.blogspot.com/2015/02/die-grundregulation-nach-pischinger.html

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INTEGRATIVE MEDICINE Graviola


Clinical Summary



Graviola, a tree prevalent in the rain forests of Africa, South America, and Southeast Asia, has been used in traditional medicine in many countries.

Extracts of graviola show antiviral (1), antiparasitic, antirheumatic, astringent, emetic (2), antileishmanial and cytotoxic (3) (4), antinociceptive, anti-inflammatory (9), antihyperglycemic (10) and anticancer effects (5)(12) (13) in vitro and in vivo.


Purported Uses
  • Cancer treatment
  • Herpes
  • Infections
  • Parasitic infections
  • Sedation

Constituents
  • Acetogenins
  • Quinolines and isoquinolines
  • Annopentocins
  • Annomuricins
  • Coreximine and reticuline
    (6) (7)  
Mechanism of Action
Annonaceous acetogenins, phytochemicals isolated from the leaves, bark and twigs of graviola, are thought to be the active ingredients.

The ethanolic extract of Annona muricata was found to inhibit the Herpes simplex virus (1) and effective against Leishmania braziliensisL. panamensis promastigotes, and the cancer cell line U 937 (3) and hepatoma cell lines (8) in vitro.


Graviola extracts were shown to be lethal to the fresh-water mollusk Biomphalaria glabrata, which acts as a host for the parasitic worm, Schistosoma mansoni (2).
Alkaloids from graviola are detrimental to the survival of dopaminergic nerve cells in vitro. This may result in neuronal dysfunction and degeneration.
Graviola-induced cell death was inhibited by glucose supplementation suggesting that cell death may have been caused by energy depletion (6)
Graviola has also been shown to stimulate serotonine receptors (7).

Graviola extracts were effective against the growth of Adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) by blocking access of cancer cells to ATP and by inhibiting the actions of plasma membrane glycoprotein (5).

They also inhibited expression of HIF-1α, NF-κB, glucose transporters, and glycolytic enzymes resulting in decreased glucose uptake and ATP production in pancreatic cancer cells (12); and downregulated EGFR expression in another study (13).
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http://www.mskcc.org/cancer-care/herb/graviola

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Graviola, (Annona muricata)
Family: Annonaceae
Genus: 
Annona
Species:
 muricata
Synonyms: 
Annona macrocarpa, A. bonplandiana, A. cearensis, Guanabanus muricatus
Common names: Graviola, soursop, Brazilian paw paw, guanábana, guanábano, guanavana, guanaba, corossol épineux, huanaba, toge-banreisi, durian benggala, nangka blanda, cachiman épineux
Part Used: Leaves, fruit, seeds, bark, roots


From 
The Healing Power of Rainforest Herbs:
GRAVIOLA
HERBAL PROPERTIES AND ACTIONS
Main Actions Other Actions Standard Dosage
  • kills cancer cells
  • relieves depression
Leaves
  • slows tumor growth
  • reduces spasms
Infusion: 1 cup 3 times daily
  • kills bacteria
  • kills viruses
Tincture: 2-4 ml 3 times daily
  • kills parasites
  • reduces fever
Capsules: 2 g 3 times daily
  • reduces blood pressure
  • expels worms
  • lowers heart rate
  • stimulates digestion
  • dilates blood vessels
  • stops convulsions
  • sedates


Graviola is a small, upright evergreen tree, 5–6 m high, with large, glossy, dark green leaves. It produces a large, heart-shaped, edible fruit that is 15–20 cm in diameter, is yellow-green in color, and has white flesh inside.

 Graviola is indigenous to most of the warmest tropical areas in South and North America, including the Amazon. The fruit is sold in local markets in the tropics, where it is called guanábana in Spanish-speaking countries and graviola in Brazil.
The fruit pulp is excellent for making drinks and sherbets and, though slightly sour-acid, can be eaten out of hand.


WORLDWIDE ETHNOMEDICAL USES
Brazil
for abscesses, bronchitis, chest problems, cough, diabetes, diarrhea, dysentery, edema, fever, intestinal colic, intestinal parasites, liver problems, neuralgia, nervousness, pain, parasites, rheumatism, spasms, worms
Caribbean
for chills, fever, flu, indigestion, nervousness, palpitations, rash, spasms, skin disease, and as a sedative
Curaçao
for childbirth, gallbladder problems, nervousness, and as a sedative and tranquilizer
Haiti
for digestive sluggishness, coughs, diarrhea, fever, flu, heart conditions, lactation aid, lice, nerves, parasites, pain, pellagra, sores, spasms, weakness, wounds, and as a sedative
Jamaica
for asthma, fevers, heart conditions, hypertension, lactation aid, nervousness, parasites, spasms, water retention, weakness, worms, and as a sedative

Malaysia
for boils, coughs, diarrhea, dermatosis, hypertension, rheumatism, and to reduce bleeding
Mexico
for diarrhea, dysentery, fever, chest colds, ringworm, scurvy, and to reduce bleeding
Panama
for diarrhea, dyspepsia, kidney, stomach ulcers, worms
Peru
for diabetes, diarrhea, dysentery, fever, hypertension, indigestion, inflammation, lice, liver disorders, parasites, spasms, tumors, ulcers (internal), and as a sedative
Trinidad
for blood cleansing, fainting, flu, high blood pressure, insomnia, lactation aid, palpitations, ringworms
U.S.A.
for cancer, depression, fungal infections, hypertension, intestinal parasites, tumors
West Indies
for asthma, childbirth, diarrhea, hypertension, lactation aid, parasites, worms
Elsewhere
for arthritis, asthma, bile insufficiency, childbirth, cancer, diarrhea, dysentery, fever, heart problems, kidney problems, lactation aid, lice, liver disorders, malaria, pain, ringworm, scurvy, stomach problems, and as a sedative
 _
http://rain-tree.com/graviola.htm#.UtZow_RdVmU
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Presence of Compounds in Graviola (Annona muricata)
http://rain-tree.com/graviola-chemicals.pdf
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Ethnomedical Information for Graviola (Annona muricata)
http://rain-tree.com/graviola-traditional-uses.pdf


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Graviola 500mg -100kpl, Immune Support, Positive Mood State


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GRAVIOLA FRUIT 4:1 powder, 100% hedelmäjauhe, 226 g



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tiistai 20. tammikuuta 2015

D-vitamiinista jaksamista talveen

D-vitamiini vaikuttaa merkittävästi elimistön kudoksiin ja soluihin. Se säätelee myös suurta määrää eri geenejä, joista osa on yhteydessä syöpiin, autoimmuunisairauksiin ja infektioihin. Tämän lisäksi D-vitamiini vaikuttaa voimakkaasti ihmisen mielialaan ja henkiseen virkeyteen. Etenkin talvella D-vitamiini on erityisen tärkeä.
Viime vuosina D-vitamiinin terveysvaikutuksia on tutkittu paljon. D-vitamiinin on todettu lieventävän monien tautien oireita. Joka kuukausi julkaistaan uusia tutkimustuloksia, jotka osoittavat, että D-vitamiini on avain perusterveyteen. Se torjuu esimerkiksi rintasyöpää, MS-tautia ja jopa skitsofreniaa.
Molekyyliviestintää tutkimalla on selvinnyt kuinka D-vitamiini torjuu tulehduksia. Miljoonilla ihmisillä on liian matala D-vitamiinitaso, mikä johtaa siihen, ettei keho kykene estämään tulehduksellisia prosesseja. Liian vähäinen D-vitamiinin saanti tarkoittaa sitä, että tulehdukset voivat edetä kehossa. Sen sijaan ihanteellinen D-vitamiinitaso on vahva puolustus tulehduksien kehittymistä vastaan. Aiheesta kirjoitettiin muun muassa The Journal of Immunology –julkaisussa.

Masennus ja mielialat
International Archives of Medicine –arkiston julkaisemien tietojen mukaan liian matala D-vitamiinitaso merkitsee 85 % korkeampaa masennusriskiä. Ne, joiden D-vitamiinitaso on ihanteellinen, elävät huomattavasti pidempään. Tutkijat kertovat:
”Vielä ei ole täysin selvää, johtaako matala D-vitamiinitaso masennukseen vai laskeeko masennus D-vitamiinitasoa kehossa. Kansanterveyden kannalta on kuitenkin erittäin tärkeä tieto, että masennus ja D-vitamiini liittyvät vahvasti toisiinsa.”
”On tärkeää tunnistaa ihmiset, joilla on suuri riski kärsiä matalasta D-vitamiinitasosta ja/tai masennuksesta. Asiaan on puututtava nopeasti, koska sillä on vakavia ja kauaskantoisia vaikutuksia ihmisen terveyteen.”
Esimerkiksi MS-taudin riski riippuu maantieteellisistä olosuhteista. Eri alueilla ihmiset altistuvat erilaisille myrkyille, jotka voivat kasvattaa riskiä. MS-taudin puhkeamiseen voi vaikuttaa myös auringonvalon määrä ja D-vitamiinitaso. Alueilla, joissa ihminen saa tarpeeksi aurinkoa, MS-tauti on paremmin hallittavissa.
D-vitamiini on melko epätavallinen vitamiini, sillä keho valmistaa sitä auringonvalosta sekä ravinnosta, joka ei sisällä vitamiinia. D-vitamiinin synty vaatii ultraviolettia säteilyä. Geenitekijät, ihonväri ja auringolle altistuminen vaikuttavat D-vitamiinitasoon.
Maailman terveysjärjestö WHO ennustaa, että 20 vuodessa masennuksesta tulee maailman merkittävin sairaus. Masennus on suurin syy ihmisten toimintakyvyttömyydelle kansainvälisesti. Siitä kärsii noin 120 miljoonaa ihmistä.
2008 hollantilaistutkijat totesivat Archives of General Psychiatry –julkaisussa, että matala D-vitamiinitaso sekä korkea parathormonitaso kasvattivat masennusriskiä. Tutkimuksessa seurattiin 1 282:n 65–95-vuotiaan elämää.
Children’s Hospital and Research Center Oaklandin tutkijoiden Bruce Amesin ja Joyce McCannin mukaan D-vitamiini on hyväksi aivojen terveydelle. McCann ja Ames totesivat, että D-vitamiini vaikuttaa myönteisesti aivojen proteiineihin, jotka ovat yhteydessä oppimiseen, muistamiseen, motoriikkaan sekä mahdollisesti jopa käytökseen ja vanhemmuuteen. Masennus on erityisen vakava ongelma iäkkäille ja se nostaa myös muiden sairauksien riskiä ja voi lyhentää elinikää.

Mikä on suositeltava määrä D-vitamiinia?
Suositeltava D-vitamiinitaso on noin 125–150 nmol/l. Ikävä kyllä ainut tapa selvittää oma D-vitamiiniarvo on käydä lääkärissä. Luotettavin tapa tehdä tämä on selvittää maksassa muodostuva 25(OH)D:n pitoisuus.
125–150 nmol/l:n suositus perustuu sille, että tutkimusten mukaan mainittu D-vitamiinitaso torjuu tehokkaasti lukuisia kroonisia sairauksia ja pidentää elinikää. Pitoisuus on yleinen terveiden asukkaiden keskuudessa trooppisella ja subtrooppisella vyöhykkeellä, jossa auringonvalosta ei ole pulaa.
talviau
Ulkoilemalla D-vitamiiniarvoistaan huolehtiva ihminen hyötyy myös muista auringonvalon luontaisista terveysvaikutuksista. Toisin sanoen auringossa oleminen on kaiken kaikkeaan terveellisempi tapa saada D-vitamiinia kuin esimerkiksi ravintolisien syöminen. Ruoan ja ravintolisien syöminen auttaa ylläpitämään suositeltavaa vitamiinipitoisuutta, mutta syömisellä ei voi korvata kaikkia auringon hyötyjä.
On kuitenkin tärkeä muistaa, että auringonpalvonnassakin on omat vaaransa: iho voi ikääntyä nopeammin ja ihosyövän riski voi kasvaa. Tällä hetkellä ei voida siis vielä sanoa, kannattaisiko D-vitamiini hankkia mieluummin auringosta vai ravinnosta.
Se on kuitenkin varmaa, että kehon 125–150 nmol/l:n D-vitamiinipitoisuus torjuu lukuisia eri tauteja ja ennakoi pitkää ikää.
Mikäli D-vitamiinin haluaa hankkia ravinnosta, kannattaa hankkia laadukasta D3-vitamiinia (kolekalsiferoli) ja vältellä tuotteita, jotka sisältävät kaliumsorbaatin kaltaisia vaarallisia säilöntäaineita.

Julkaistu 5.1.2015 englanniksi Prevent Disease –verkkosivuilla.
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http://www.magneettimedia.com/d-vitamiinista-jaksamista-talveen/

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lauantai 17. tammikuuta 2015

MAGNESIUM SHOWS SIGNIFICANT BENEFITS FOR BLOOD SUGAR CONTROL

By Greg Arnold, DC, CSCS, November 26, 2014, abstracted from “Higher Magnesium Intake Reduces Risk of Impaired Glucose and Insulin Metabolism and Progression from Prediabetes to Diabetes in Middle-Aged Americans” in Diabetes Care, February 2014
 

There are currently 29.1 million Americans with diabetes (21 million diagnosed, 8.1 million undiagnosed at a cost of $245 billion each year (1)) and 86 million Americans with “prediabetes” (defined as having fasting plasma sugar levels between 5.6 and 7.0 millimoles/L (2)). A common condition in these patients is an increased level of the inflammatory protein called high-sensitivity C-reactive protein (3) which can damage blood vessels in a way that leads to high blood pressure and heart disease.

 
Now a new study (4) suggests that magnesium intake can help slow the progress of prediabetes to type 2 diabetes. The study involved 2,582 subjects aged 26 to 81.  The subjects were comprised of 928 with impaired fasting glucose (between 5.6 and 7.0 millimoles/Liter) and impaired glucose tolerance (defined as having blood sugar levels 2 hours after eating between 7.8 and 11.1 mmol/L) and 1,654 without blood sugar problems. Over the course of seven years, researchers measured the progression of each subject’s diabetes risk by measuring their blood sugar levels and insulin levels.
 
The researchers noted that those with the highest intake of magnesium consumed an average of 395.6 milligrams per day (359.4 mg from food, 36.3 mg from supplements) and those with the lowest intake of magnesium consumed 227 mg per day (224.3 mg/d from food, 2.7 mg/d from supplements). Among the 928 subjects with blood sugar problems, those in the high magnesium intake group had a 37% lower risk of progressing to type 2 diabetes (p = 0.02). The 1,654 subjects without blood sugar problems had a 32% lower risk of progressing to type 2 diabetes (p = 0.05), compared to those with the lowest magnesium intake.
 
When suggesting how magnesium elicits these benefits on blood sugar, the researchers cited studies showing a decreased efficiency of insulin receptors in the absence of magnesium (5), decreased function of the cells that produce insulin (called beta cells) in the absence of magnesium (6) and a reverse effect of insulin on magnesium levels where high levels of insulin stimulate magnesium excretion from the body (7).
 
For the researchers, “Magnesium intake may be particularly beneficial in offsetting risk of developing diabetes among those at high risk” and that “These findings support a role for higher magnesium intake in those at high risk of developing diabetes and the need for large, randomized trials to confirm these observations.”
 
Greg Arnold is a Chiropractic Physician practicing in Hauppauge, NY.  You can contact Dr. Arnold directly by emailing him atPitchingDoc@msn.com or visiting his web site at www.PitchingDoc.com
 
Reference:
1.     “National Diabetes Statistics Report, 2014” posted on the CDC website
2.     The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Follow up report on the diagnosis of diabetes mellitus. Diabetes Care 2003;26:3160e3167
3.     Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 2004;27:813e823
4.     Hruby A. Higher Magnesium Intake Reduces Risk of Impaired Glucose and Insulin Metabolism and Progression From Prediabetes to Diabetes in Middle-Aged Americans. Diabetes Care 2014 Feb;37(2):419-27. doi: 10.2337/dc13-1397. Epub 2013 Oct 2
5.     Su´arez A, Pulido N, Casla A, Casanova B, Arrieta FJ, Rovira A. Impaired tyrosinekinase activity of muscle insulin receptors from hypomagnesaemic rats. Diabetologia 1995;38:1262–1270
6.     Barbagallo M, Dominguez LJ. Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Arch Biochem Biophys 2007; 458:40–47
7.     G¨unther T. The biochemical function of Mg2+ in insulin secretion, insulin signal transduction and insulin resistance. Magnes Res 2010;23:5–18

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Description
  • With B-Complex & Vitamin C
  • Vegetarian Formula
  • A Dietary Supplement
  • GMP Quality Assured
Calcium & Magnesium are essential minerals that work synergistically with one another to promote enhanced absorption. Calcium is necessary for strong bones and teeth, and Magnesium is important for healthy enzymatic activity. In addition, NOW Cal-Mag Stress Formula provides a full spectrum of B-Vitamins and Vitamin C.
Suggested Use
As a dietary supplement, take 2 tablets daily, preferably with meals.
Other Ingredients
Cellulose, stearic acid (vegetable source), croscarmellose sodium, silica, magnesium stearate (vegetable source) and vegetable coating.
Contains no sugar, salt, starch, yeast, wheat, gluten, soy, milk, egg or preservatives.

Key FeaturesSupplement Type: Minerals Supplement, Vitamins & Minerals Supplement Category: Dietary SupplementProduct Type: TabletsNutritional Ingredients: Vitamin B
Supplement Facts
Serving Size: 2 Tablets
Servings Per Container: 50
Amount Per Serving / % Daily Value

Vitamin C (as Ascorbic Acid) 120 mg / 200%
Thiamine (Vitamin B-1) (from Thiamine HCl) 10 mg / 667%
Riboflavin (Vitamin B-2) 5 mg / 294%
Niacin (Vitamin B-3) (as Niacinamide) 40 mg / 200%
Vitamin B-6 (from Pyridoxine HCl) 5 mg / 250%
Folate (Folic Acid) 800 mcg / 200%
Vitamin B-12 (as Cyanocobalamin) 20 mcg / 333%
Biotin 300 mcg / 100%
Pantothenic Acid (Vitamin B-5) (from Calcium Pantothenate) 20 mg / 200%
Calcium (from 80% Calcium Carbonate, 10% Calcium Citrate, 10% Amino Acid Chelate) 1.0 g (1,000 mg) / 100%

Magnesium (from 80% Magnesium Oxide, 10% Magnesium Citrate, 10% Amino Acid Chelate) 500 mg /     125%
Choline (as Choline Bitartrate) 20 mg † Inositol 20 mg † PABA 10 mg


Daily Value not established.

keskiviikko 31. joulukuuta 2014

Glukuronidaatio on prosessi, joka muuttaa aineita vesiliukoisemmiksi

Sen seurauksena ne ovat helpommin poistettavissa elimistöstä virtsan mukana. Kun glukuronidaatiota estetään, joidenkin aineiden biosaatavuus näyttää paranevan. Biosaatavuudella tarkoitetaan ravintoaineiden imeytyvyyttä elimistössä.

 

CALSIUM D -GLUKARAATTI

Glukuronidaatio on kapasiteetiltaan suurin ihmisen vierasaineiden metaboliaan keskittynyt aineenvaihduntareitti


Siinä toksiset (myrkylliset) yhdisteet sidotaan maksassa glukuronihappoon, jotta ne voidaan poistaa kehosta turvallisesti. Betaglukuronidaasi on yksi prosessiin osallistuvista entsyymeistä. Sitä esiintyy luontaisesti useissa kudoksissa ja soluissa.
Kalsium-d-glukaraatti on glukaarihapon patentoitu muoto, jonka vaikutus kohdistuu betaglukuronidaasin entsyymaattiseen aktiivisuuteen.  3 kpl USA Patenttia.





Vierasainemetabolia 

Yleisfarmakologiaa ja –toksikologiaa

Yleistä
Lähes kaikissa elävissä organismeissa on kehittynyt kyky päästä eroon niille vieraista aineista. Ihminen on jatkuvasti altistunut lukemattomille vieraille aineille, kuten kasvien syntetisoimille aineille, ravinnon lisäaineille, saasteille, nautintoaineille ja lääkkeille. Nämä elimistölle vieraat aineet saatetaan erityskelpoiseen muotoon muuttamalla niiden rakennetta metabolian avulla. Koska elimistö ei tee eroa siinä, ovatko siihen tulevat vieraat aineet esimerkiksi saasteita vai lääkkeitä, käytetään yleistermiä vierasainemetabolia eli biotransformaatio.

Lääkeainemetabolia on osa yleistä vierasainemetaboliaa 

Useimpien lääkeaineiden vaikutus elimistössä päättyy metabolian ja munuaisten kautta tapahtuvan erittymisen avulla. Metabolian päätehtävä on muuttaa elimistöön tullut vieras aine erityskelpoiseen muotoon. Tämä tapahtuu useiden erilaisten entsymaattisten reaktioiden kautta, joissa lääkeaine muutetaan vesiliukoisemmaksi. 

Vierasainemetabolian tärkeyttä kuvaa hyvin kemikaalien käyttäytyminen elimistössä. Pystyäkseen imeytymään elimistön kalvojen läpi aineen tulee olla lipidiliukoinen. Verenkiertoon imeytynyt aine suodattuu munuaisten glomeruluksiin ja tubuluksiin. Tubuluksista lipidiliukoinen aine imeytyy seinämän läpi takaisin verenkiertoon. Jos elimistössä ei olisi mekanismia, joka muuttaa aineen vesiliukoiseksi, se ei erittyisi vaan lipidiliukoinen aine jäisi elimistöön ja kumuloituisi kudoksiin.Esimerkiksi hyvin lipidiliukoisen ja lyhytvaikutteisen barbituraatin, tiopentaalin, erittyminen pois elimistöstä kestäisi sadan vuoden ajan, ellei se metaboloituisi esiliukoisemmaksi.
Vierasainemetabolian tapahtumapaikat 
Tärkein vierasaineita metaboloiva elin on maksa, koska metaboloivien entsyymien pitoisuudet ovat siellä suurimmat. Muita metaboloivia elimiä ovat keuhkot, iho ja munuainen.
Suolistossa tapahtuu varsin paljon vierasainemetaboliaa, ja siihen osallistuvat sekä suolen seinämä että suoliston bakteerit. Yhteistä näille elimille on se, että vierasaineet tulevat niiden kautta elimistöön. Lisäksi vierasaine -metaboliaa tapahtuu aivoissa, istukassa sekä monissa endokriinisissä kudoksissa.
Solun sisällä vierasaineiden metabolia tapahtuu pääasiassa endoplasmiseen kalvostoon kiinnittyneiden entsyymien avulla. Kun solu ja sen organellit rikotaan, voidaan sentrifugoimalla erottaa ns. mikrosomaalinen fraktio, joka sisältää pääasiassa solukalvoston osia.
Mikrosomeista voidaan mitata suuria pitoisuuksia vierasaineita hapettavia entsyymejä. Metaboloivia entsyymejä on myös vapaana solulimassa.

Metaboliareitit 
Vierasaineita metaboloivat entsyymit jaotellaan kahteen pääryhmään, I vaiheen ja II vaiheen entsyymeihin. I vaiheen entsyymit katalysoivat funktionaalisen ryhmän, esimerkiksi hydroksyyliryhmän, muodostumisen vierasaineeseen. II vaiheen entsyymit puolestaan
konjugoivat vierasaineen johonkin toiseen molekyyliin, kuten glutationiin tai glukuronidiin. Taulukossa 5-1 on lueteltu tärkeimpiä I ja II vaiheen reaktioita. Useimmiten I vaiheen entsyymit muodostavat ensin vierasaineeseen funktionaalisen ryhmän, johon II vaiheen entsyymit liittävät vesiliukoisen molekyylin. Joskus vierasaine konjugoituu suoraan ilman I vaiheen metaboliaa (kuva 5-1).

Metabolialla voi olla neljänlaisia seurauksia:        
1) Aktiivisesta lääkeaineesta syntyy inaktiivinen metaboliitti.
Metaboliitti on vesiliukoisempi kuin kanta-aine, ja siksi se erittyy pois elimistöstä munuaisten, sapen tai keuhkojen kautta. Tämä on yleisin metabolian kulku, ja näin tapahtuu useimpien lääkeaineiden metaboloituessa.
2) Aktiivisesta lääkeaineesta syntyy aktiivinen metaboliitti. Myös tätä tapahtuu usein. Esimerkiksi analgeeteista asetyylisalisyylihappo muuttuu salisyylihapoksi ja fenasetiini parasetamoliksi. Joskus metaboliitin ominaisuudet poikkeavat kanta-aineesta. Esimerkiksi fenyylibutatsonin metaboliitti oksifenbutatsoni on voimakkaampi tulehduksen estäjä kuin fenyylibutatsoni ja sen puoliintumisaika on pitempi. Toisinaan lääkeaine metaboloituu sekä aktiivisiksi että inaktiivisiksi yhdisteiksi. 
3) Inaktiivisesta lääkeaineesta syntyy aktiivinen metaboliitti. Tästä on esimerkkinä syöpälääke syklofosfamidi, jonka täytyy aktivoitua useaksi alkyloivaksi metaboliitiksi estääkseen solunjakautumista. Myös a1-reseptorin antagonisti fenoksibentsamiini on itse tehoton ja aktivoituu metaboloitumalla.
4) Aktiivisesta tai inaktiivisesta lääkeaineesta syntyy toksinen metaboliitti.
Parasetamolin liika-annon yhteydessä voi syntyä maksassa N-hydroksiparasetamolia, joka edelleen muuttuu reaktiiviseksi, maksasoluja tuhoavaksi yhdisteeksi.


 Tunnetaan myös lukuisia metabolisesti aktivoituvia vierasaineita, jotka eivät ole käytössä lääkkeinä. 
Esimerkiksi suuri osa syöpää aiheuttavista aineista (kemiallisista karsinogeeneista) muuttuu vasta elimistöön päästyään varsinaiseen syöpää aiheuttavaan muotoon metabolisen aktivaation kautta.

Kuva 5-1. Vierasainemetabolian kaksi päävaihetta.


Useimmiten I vaiheen entsyymit muodostavat vierasaineeseen funktionaalisen ryhmän, johon II vaiheen konjugoivat entsyymit liittävät jonkin endogeenisen molekyylin, esimerkiksi glukuronidin.
Toisinaan vierasaine konjugoituu suoraan.


-
http://www.medicina.fi/fato/05.pdf 

 
Detoxifying the Body

In Lessons from the Miracle Doctors, I cover the liver in some detail, describing how it detoxifies the body. The main process that it uses for doing this is called conjugation - - literally combining toxins with other substances to neutralize them or prepare them for elimination.
  • This can be the combining of proteins with vitamin isolates (as found in most supplements) to detoxify them and make them usable by the cells of the body.
  • The combining of glutathione with harmful substances such as nicotine to neutralize their toxic effect.
  • The combining of glucoronic acid with carcinogens such as synthetic estrogens in a process called glucuronidation (the main focus of this newsletter) whereby toxins are literally "washed" from the body.

Glucuronidation 

Glucuronidation enables the body to rid itself of foreign elements including xenoestrogens, pollutants, toxins, and carcinogens. Glucuronidation is literally a process in which glucuronic acid is conjugated (joined) to various toxins in the liver so that they can be excreted through the bile or urine. It represents one of the major pathways for the body to rid itself of foreign substances and is responsible for removing a number of highly toxic chemicals from our system, such as polycyclic aromatic hydrocarbons, steroid hormones, nitrosamines, heterocyclic amines, aromatic amines, and fungal toxins. It also removes "used" hormones and synthetic hormones from the body. Glucuronidation, then, represents a major means of converting most drugs, steroids, and many toxic and "environmental" substances to metabolites that can be excreted into the urine or bile. The bottom line is that glucuronidation is one of the main ways the body purges itself of carcinogenic substances.
In times past, glucuronidation was sufficient to protect us from cancer. Two things have changed in the last hundred years that contribute significantly to the increase in the incidence of cancer we now see.
  1. We are exposed to far more carcinogens in our food supply, water, and air than ever before. (For example, there are over 2,000 known carcinogens just in the average drinking water in the United States today.)
  2. Thanks to changes in diet and the overuse of antibiotics in medicine and our food supply, the levels of the enzyme called beta-glucuronidase are much much higher in our bodies than ever before.
Beta-glucuronidase is an enzyme produced by E. Coli bacteria in the gut. Glucuronidase literally breaks the bond between the toxic compounds the body is trying to eliminate and the glucuronic acid that is responsible for eliminating them. When beta-glucuronidase breaks the bond, the hormone or toxin is once again released into the body instead of being excreted. Elevated glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers like breast, prostate, and colon cancers.
Can we reduce our exposure to beta glucuronidase? Absolutely.
Taking probiotic supplements can dramatically ...
Calcium D-Glucarate
And there is another way. Calcium D-Glucarate (a calcium salt found in foods such as apples, grapefruit, broccoli,
Brussels sprouts, cabbage, lettuce, and alfalfa) suppresses beta-glucuronidase and restores the glucuronidation detoxification pathway. The beauty of Calcium D-Glucarate is that not only does it neutralize the effects of beta-glucuronidase, but it actually strengthens the bond between glucuronic acid and the cancer-causing toxins that are being flushed from the body.
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//The Baseline of Health Foundation 


Summary (All Essential Benefits/Effects/Facts & Information)




For the most part, Calcium-D-Glucarate is just known to be a β-glucuronidase inhibitor via its metabolite D-glucaro-1,4-lactone. The process of 'glucuronidation' is a detoxification process where a group (known as a glucuronide) is attached to a hydrophobic molecule to make it more water soluble, and then the kidneys can better facilitate its removal from the body. This process is positively mediated by the glucuronosyltransferase enzyme, and negatively mediated by the β-glucuronidaseenzyme; as such, inhibiting the negative regulator (the enzyme that removes the glucuronide) indirectly increases the activity of this pathway.
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User Reviews & Ratings - CALCIUM D-GLUCARATE

Calcium D-glucarate is a chemical. It is similar to a naturally occurring chemical called glucaric acid. Glucaric acid is found in our bodies as well as in fruits and vegetables such as oranges, apples, brussels sprouts, broccoli, and cabbage. Calcium D-glucarate is made by combining glucaric acid with calcium to make supplements that people use for medicine.

Calcium D-glucarate is used for preventing breastprostate, and coloncancer; and for removing cancer-causing agents, toxins, and steroid hormones from the body.

How does it work?

Calcium D-glucarate might lower estrogen levels, and this is thought to be helpful in treating some people with hormone-dependent cancers. There isn't enough evidence to support the use of calcium D-glucarate for preventing cancer in humans.
Read user comments about the side effects, benefits, and effectiveness of CALCIUM D-GLUCARATE.
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Calcium D-Glucarate, 60 Tablets 

€ 28,90  sis. ALV 14%