December 2018
Health authorities are less enthusiastic.
The Endocannabinoid System For Dummies
Have you ever been confused about the endocannabinoid system?
Educate yourself.
This guide will tell you everything you need to know.
ANNA WILCOX
Have you ever wondered how THC works?
Well, it just-so-happens to be a similar shape to a compound our bodies create naturally. Thanks to its shape, THC is able to tap into a network in our bodies called the endocannabinoid system. It’s this ability that gives THC it’s psychoactive effects. But, what is the endocannabinoid system and what does it do?
To help you understand, we’ve created a handy guide to the endocannabinoid system for dummies.
https://graviolateam.blogspot.com/2018/07/the-endocannabinoid-system-for-dummies.html
___
It's the extract from cannabis that has
healing qualities across a range of diseases, from
epilepsy to cancer. Now even Coca-Cola is interested.
epilepsy to cancer. Now even Coca-Cola is interested.
Paige
and Matt Figi were at their wit's end. Their five-year-old daughter,
Charlotte, had a rare form of epilepsy
known as Davet syndrome, and she was suffering around 300 grand mal seizures a week.
Her heart had stopped several times, and she was put into a medically induced coma just to give her small
body some respite.
known as Davet syndrome, and she was suffering around 300 grand mal seizures a week.
Her heart had stopped several times, and she was put into a medically induced coma just to give her small
body some respite.
There was nothing
else the doctors could do for her.
Desperately
searching the internet for solutions, Paige and Matt read several
accounts of how CBD oil —
a derivative of cannabis and hemp—had helped people with epilepsy. Although they were worried about
giving a small child a form of cannabis, they also felt they had nothing to lose. Within a year, their boldness
was rewarded, and Charlotte's seizures had all but stopped.
a derivative of cannabis and hemp—had helped people with epilepsy. Although they were worried about
giving a small child a form of cannabis, they also felt they had nothing to lose. Within a year, their boldness
was rewarded, and Charlotte's seizures had all but stopped.
Since
her story was featured on CNN in 2013, there has been "an
explosion of research," according to the
National Institutes of Health's Pal Pacher, a pharmacologist. Animal tests, and even small studies on a
handful of people, have suggested that CBD can help a range of health problems from epilepsy to the
healing of bone fractures, pain, inflammation, Crohn's disease and even some cancers.
National Institutes of Health's Pal Pacher, a pharmacologist. Animal tests, and even small studies on a
handful of people, have suggested that CBD can help a range of health problems from epilepsy to the
healing of bone fractures, pain, inflammation, Crohn's disease and even some cancers.
CNN documentary on Charlotte's Web, medical marijuana treating seizure disorders
Health authorities are less enthusiastic.
CBD (cannabidiol) is the therapeutic ongredient in cannabis—first discovered back in 1940—and it's sometimes called "the hippie's disappointment" because it doesn't make the user high; that's the function of another ingredient, THC (tetrahydrocannabinol).
Medical
marijuana, as it's also called, is permitted in many Western
countries as long as the THC content
is kept to just 0.2 percent.
is kept to just 0.2 percent.
But
cannabis is still listed as a schedule 1 drug—the same
classification given to heroin—by the US and
UK governments, at least at the national level. This has impeded research as well as its more widespread
use, since licensed practitioners are often the only ones who can prescribe high-dose CBD.
UK governments, at least at the national level. This has impeded research as well as its more widespread
use, since licensed practitioners are often the only ones who can prescribe high-dose CBD.
However,
the tide is certainly turning. The first CBD-based drugs are getting
approval; the first was Sativex,
a 1-to-1 ratio of CBD and THC, to treat the painful muscle spasms seen in multiple sclerosis, and the
second, Epidiolex, was approved this year by the US Food and Drug Administration (FDA) to treat epilepsy.
Both drugs are made by British drug company GW Pharma.
a 1-to-1 ratio of CBD and THC, to treat the painful muscle spasms seen in multiple sclerosis, and the
second, Epidiolex, was approved this year by the US Food and Drug Administration (FDA) to treat epilepsy.
Both drugs are made by British drug company GW Pharma.
Despite
the restrictions, CBD is "a Disneyland for pharmacologists,"
said Francisco Guimaraes, a
pharmacologist at the University of São Paulo in Brazil, who has discovered that it helps new neurons
to grow in the brain, and especially the hippocampus, which is linked to depression and anxiety.
pharmacologist at the University of São Paulo in Brazil, who has discovered that it helps new neurons
to grow in the brain, and especially the hippocampus, which is linked to depression and anxiety.
Although
CBD seems to help with a wide range of conditions, nobody is quite
sure how it works.
Our body has cannabinoid receptors—CB1 receptors are found in the brain and help regulate pain,
movement and cognitive abilities, and CB2 receptors are mainly found in the immune system and
control inflammation and pain—and it's thought that taking CBD helps the body develop more of its
own cannabinoids, which could trigger healing.
Our body has cannabinoid receptors—CB1 receptors are found in the brain and help regulate pain,
movement and cognitive abilities, and CB2 receptors are mainly found in the immune system and
control inflammation and pain—and it's thought that taking CBD helps the body develop more of its
own cannabinoids, which could trigger healing.
Here
are some research findings:
Fractures.
CBD helps fractures heal more quickly. On the face of it, it's bizarre—but it actually explains
why CBD could help with so many other conditions, too.
CBD helps fractures heal more quickly. On the face of it, it's bizarre—but it actually explains
why CBD could help with so many other conditions, too.
When
we suffer a fracture, CBD activates the processes that make bones
stronger and accelerates the
building of new bone. Afterward, the bone is stronger than before, making it less likely to fracture in the
future, say researchers at Tel Aviv University who made the discovery when they tested both CBD and THC
on a group of laboratory rats.
building of new bone. Afterward, the bone is stronger than before, making it less likely to fracture in the
future, say researchers at Tel Aviv University who made the discovery when they tested both CBD and THC
on a group of laboratory rats.
The
CBD group's bones healed more quickly, while THC didn't have the
same effect.
This could mean that CBD can prevent osteoporosis and other bone problems as we age, the researchers
say.1
This could mean that CBD can prevent osteoporosis and other bone problems as we age, the researchers
say.1
Pain.
Pain
relief was one of the first uses of CBD, and research continues to
demonstrate that it's an effective
analgesic.
analgesic.
In one experiment on
laboratory rats, a derivative of CBD, MDA19, relieved neuropathic
pain caused by
nerve damage, which is common in people suffering from trauma and diabetes. Not surprisingly, researchers
from the University of Texas MD Anderson Cancer Center in Houston also discovered that the pain relief
was greater with higher doses.2
nerve damage, which is common in people suffering from trauma and diabetes. Not surprisingly, researchers
from the University of Texas MD Anderson Cancer Center in Houston also discovered that the pain relief
was greater with higher doses.2
Another
study, which explored pain's impact on sleep, discovered that half
the 2,000 patients tested started
to enjoy a full night's sleep after taking CBD or a combination of CBD and THC. There were no serious
side-effects or dosages that caused problems, but it helped the patients—suffering from multiple sclerosis,
peripheral neuropathic pain, cancer pain and rheumatoid arthritis—get some high-quality rest.3
to enjoy a full night's sleep after taking CBD or a combination of CBD and THC. There were no serious
side-effects or dosages that caused problems, but it helped the patients—suffering from multiple sclerosis,
peripheral neuropathic pain, cancer pain and rheumatoid arthritis—get some high-quality rest.3
Inflammation.
CBD is also an anti-inflammatory. It communicates with two receptors in the body—CB1 and
CB2—and it's CB2 that regulates the inflammatory response. When their CB2 receptors are activated,
immune cells release fewer inflammatory chemicals known as cytokines. In tests on mice and rats,
CBD has shown promise for conditions including arthritis, swelling, and inflammation in the brain and
intestines.4
CBD is also an anti-inflammatory. It communicates with two receptors in the body—CB1 and
CB2—and it's CB2 that regulates the inflammatory response. When their CB2 receptors are activated,
immune cells release fewer inflammatory chemicals known as cytokines. In tests on mice and rats,
CBD has shown promise for conditions including arthritis, swelling, and inflammation in the brain and
intestines.4
Crohn's
disease.
Crohn's disease is a form of inflammatory bowel disease that doesn't respond to conventional
Crohn's disease is a form of inflammatory bowel disease that doesn't respond to conventional
treatment. When 21 sufferers
were given cannabis or a placebo, five of 11 in the cannabis group
achieved
complete remission of their symptoms, compared to just one of 10 in the placebo group.
Ten in the cannabis group also reported a marked reduction in symptoms.
complete remission of their symptoms, compared to just one of 10 in the placebo group.
Ten in the cannabis group also reported a marked reduction in symptoms.
The eight weeks of treatment
achieved "significant clinical, steroid-free benefits,"
the researchers said. 5
Alzheimer's
disease.
Amyloid beta is a protein that forms into plaques in the brain that are regularly seen in Alzheimer's
Amyloid beta is a protein that forms into plaques in the brain that are regularly seen in Alzheimer's
patients—and cannabis
can help remove them. Researchers from the Salk Institute in San
Diego, California,
tested cannabis compounds, including THC, on brain cells grown in the lab, and found they reduced amyloid
beta protein levels and completely eliminated the inflammatory response.6
tested cannabis compounds, including THC, on brain cells grown in the lab, and found they reduced amyloid
beta protein levels and completely eliminated the inflammatory response.6
Epilepsy.
The treatment of epilepsy was what put CBD on the therapeutic map. The bulk of the scientific evidence for
The treatment of epilepsy was what put CBD on the therapeutic map. The bulk of the scientific evidence for
its effectiveness comes from
Colorado, one of the first states to legalize marijuana, although
the results have
been mixed.
been mixed.
In
one study of 58 children and adolescents given CBD, one-third cut
their rate of seizure by at least half, but
21 percent reported an increase in seizures. CBD fared better in cases of infantile spasms and a severe
form of epilepsy called Lennox-Gastaut syndrome; of the 53 children treated, 92 percent had a reduction in
seizures.7
21 percent reported an increase in seizures. CBD fared better in cases of infantile spasms and a severe
form of epilepsy called Lennox-Gastaut syndrome; of the 53 children treated, 92 percent had a reduction in
seizures.7
In
a separate study of Lennox-Gastaut syndrome, sufferers reported a 42
percent reduction in 'drop seizures'
— where there is a severe loss of muscle control and balance—when they were given 20mg CBD, and this
fell slightly to 37 percent in those given 10mg. 8
— where there is a severe loss of muscle control and balance—when they were given 20mg CBD, and this
fell slightly to 37 percent in those given 10mg. 8
To
get its first CBD drug, Epidiolex, approved, GW Pharma put together
four studies that showed CBD's
effectiveness in treating severe cases of epilepsy. In one study of 261 children, nearly half experienced at
least a 50 percent reduction in seizures. 9
effectiveness in treating severe cases of epilepsy. In one study of 261 children, nearly half experienced at
least a 50 percent reduction in seizures. 9
Cancer.
CBD appears to triple the survival rate for pancreatic cancer, at least in animals. In humans, pancreatic
cancer is considered virtually untreatable—chemotherapy achieves a five-year survival rate of just 7 percent.
But when researchers from Queen Mary University in London gave CBD to mice with the disease, their
survival rate tripled.
CBD appears to triple the survival rate for pancreatic cancer, at least in animals. In humans, pancreatic
cancer is considered virtually untreatable—chemotherapy achieves a five-year survival rate of just 7 percent.
But when researchers from Queen Mary University in London gave CBD to mice with the disease, their
survival rate tripled.
A similar effect in humans could see CBD "in use in
cancer clinics almost immediately," said lead researcher
Marco Falasca. 10
Marco Falasca. 10
CBD
triggers cell death (apoptosis) in breast cancer cells, researchers
from the Beth Israel Deaconess
Medical Center in Boston discovered in laboratory tests on cancer cell lines,11
Medical Center in Boston discovered in laboratory tests on cancer cell lines,11
and
it also stops lung cancer cells from growing and spreading, a
separate study found.12
It
even stops the growth of aggressive, life-threatening breast cancer
and seems to be especially effective in
cases of so-called 'triple-negative' breast cancer. It appears to interrupt the cells' signaling ability to prevent
them from spreading. 13
cases of so-called 'triple-negative' breast cancer. It appears to interrupt the cells' signaling ability to prevent
them from spreading. 13
CBD
spray is an effective pain reliever for patients with advanced and
end-stage cancer. In one test on 43
cancer patients, researchers from a hospice in Shropshire, UK, discovered that the spray reduced pain and
helped the patients' insomnia and fatigue. 14
cancer patients, researchers from a hospice in Shropshire, UK, discovered that the spray reduced pain and
helped the patients' insomnia and fatigue. 14
CBD
also slows the growth of colon cancer cells. Interestingly, the CBD
didn't affect healthy cells, say
researchers from the University of Aberdeen in Scotland. But it seems to activate CB1 and CB2 receptors
that help to slow the spread of the cancer.15
researchers from the University of Aberdeen in Scotland. But it seems to activate CB1 and CB2 receptors
that help to slow the spread of the cancer.15
Making
things go better
CBD
has caught the interest of beverage giant Coca-Cola. The company is
in preliminary talks with
Canadian cannabis company Aurora Cannabis about introducing a new line of CBD-infused drinks.
Canadian cannabis company Aurora Cannabis about introducing a new line of CBD-infused drinks.
Although
Coca-Cola hopes that the new range—should it ever see the light of
day—would eventually be
available around the world, it's no accident that the company is talking to a Canadian producer.
Last October, the country became only the second in the world—after Venezuela—to fully legalize cannabis.
available around the world, it's no accident that the company is talking to a Canadian producer.
Last October, the country became only the second in the world—after Venezuela—to fully legalize cannabis.
Coca-Cola
is not the first entrant into the CBD beverage market. Brands
such as Dirty Lemon and Beboe
are already available, but Coca-Cola would be the first global conglomerate that takes an interest.
are already available, but Coca-Cola would be the first global conglomerate that takes an interest.
The
new drink would be positioned as "a functional wellness
beverage," said Coca-Cola spokesman
Kent Landers on Bloomberg News TV.
Kent Landers on Bloomberg News TV.
Joint
gains
Think
cannabis, and images of smoking pot or weed come to mind. That's
because of the THC
(tetrahydrocannabinol)
(tetrahydrocannabinol)
in cannabis that makes
people feel 'high,' but it's just one of the 113 cannabinoids found
in hemp plants.
CBD
(cannabidiol), which was discovered and isolated in laboratory tests
in 1940, makes up around 40
percent of the extract from a hemp plant. Different cannabis plants deliver various levels of THC and CBD
naturally, but for any CBD product to be allowed for sale in stores, the THC level must be below 0.2 percent.
percent of the extract from a hemp plant. Different cannabis plants deliver various levels of THC and CBD
naturally, but for any CBD product to be allowed for sale in stores, the THC level must be below 0.2 percent.
CBD
can be taken several ways: by smoke inhalation or vapor, as an
aerosol spray into the cheek, or as an
oil, often placed under the tongue.
oil, often placed under the tongue.
Although
CBD won't make you high, it can cause drowsiness, diarrhea and
sleeping problems.
(Vol. 3 Issue 10) in Alzheimer's, Bowel disease, Breast cancer, CBD, Cancer, Cannabis, Crohn's disease,Depression, Drugs, Epilepsy, Fracture, Healing,
Inflammatory, Inflammatory bowel disease, Insomnia
(Vol. 3 Issue 10) in Alzheimer's, Bowel disease, Breast cancer, CBD, Cancer, Cannabis, Crohn's disease,Depression, Drugs, Epilepsy, Fracture, Healing,
Inflammatory, Inflammatory bowel disease, Insomnia
___
The Endocannabinoid System For Dummies
(We’ve Made It Easy For You)
HEALTH
Have you ever been confused about the endocannabinoid system?
Educate yourself.
This guide will tell you everything you need to know.
ANNA WILCOX
JUL 28, 2016
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Have you ever wondered how THC works?
Well, it just-so-happens to be a similar shape to a compound our bodies create naturally. Thanks to its shape, THC is able to tap into a network in our bodies called the endocannabinoid system. It’s this ability that gives THC it’s psychoactive effects. But, what is the endocannabinoid system and what does it do?
To help you understand, we’ve created a handy guide to the endocannabinoid system for dummies.
https://graviolateam.blogspot.com/2018/07/the-endocannabinoid-system-for-dummies.html
___
A collection of links to clinical studies, papers and reference guides for medical cannabis use
MEDICAL CONDITIONS THAT CAN BE TREATED WITH CANNABIS: A - C
Free PDF Files relating to medical cannabis use
"If (Marijuana) were unknown, it's discovery would no doubt be hailed as a medical breakthrough. Scientists would praise it's potential for treating everything from pain to cancer and marvel at it's rich pharmacopoeia; many of whose chemicals mimic vital molecules in the human body." - The Economist:
Alzheimer's Disease, How I Stopped and Reversed It
Marijuana may extend life expectancy of lou gehrig disease patients
Marijuana as ALS treatment Medical marijuana and Amyotrophic Lateral Sclerosis
Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa
Role of endocannabinoids and their analogues in obesity and eating disorders Brain type 1 cannabinoid receptor availability in patients with anorexia and bulimia nervosa
Arthritis (rheumatoid or osteoporosis)
Is marijuana an effective treatment for the symptoms of arthritis?
Cannabis drug cuts arthritis pain What is the role of marijuana in arthritis?
Can marijuana help people with asthma or other breathing disorders?
Cannabis Medical Dictionary: Asthma/
Cannabis cures asthma
ADHD and marijuana
Applying ADHD lessons to medical marijuana Medical Marijuana: No longer just for adults
Cannabinoinds Therapeutic Effects on ASVD
Cannabis chemical 'helps heart'
Cannabinoids and Atherosclerotic Coronary Heart Disease (PDF)
Marijuana-Like Chemical May Help Autism
Can cannabis improve autism? NORML Backs Survey On Marijuana And Autism
Study: Pot May Improve Cognitive Functioning in Bipolar Disorder Bipolar Disorder May Be Ameliorated By Pot Smoking, Research Finds Cannabinoids in Bipolar disorder
Scientists find cannabis compound stops metastasis in aggressive cancers
Cannabis treatment could stop breast cancer
Can cannabis treatment cure cancer
Scientists find cannabis compound stops metastasis in aggressive cancers Cannabis compound could stop breast cancer Cannabis can successfully treat Breat Cancer - More... Cannabis oil treating serious skin cancer (WARNING GRAPHIC CONTENT)
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Free PDF Files relating to medical cannabis use
"If (Marijuana) were unknown, it's discovery would no doubt be hailed as a medical breakthrough. Scientists would praise it's potential for treating everything from pain to cancer and marvel at it's rich pharmacopoeia; many of whose chemicals mimic vital molecules in the human body." - The Economist:
Alcohol and opiate abuse
Cannabis can ease both the physical and psychological effects associated with withdrawal from both of these addictive substances.
Cannabis-med studies on marijuana treatment for alcohol and drug abuse
Marijuana in treating drug and alcohol addiction
Medical marijuana as a treatment for alcoholism addiction
Cannabis-med studies on marijuana treatment for alcohol and drug abuse
Marijuana in treating drug and alcohol addiction
Medical marijuana as a treatment for alcoholism addiction
Alzheimer’s disease
Research shows that cannabis may prevent the formation of deposits in the brain associated with
this degenerative disease.
Information from medicalmarijuana.procon.org
Cannabis and the treatment of dementia
Cannabidiol: a promising drug for neurodegenerative disorders?
this degenerative disease.
Information from medicalmarijuana.procon.org
Cannabis and the treatment of dementia
Cannabidiol: a promising drug for neurodegenerative disorders?
Neurodegeneration is a feature common to dementia sufferers.
This has led to interest in whether cannabinoids may be clinically useful in the treatment of people with dementia.
Recent studies have shown that cannabinoids may be effective at interrupting the pathological process in Alzheimer’s.
The Professional version and complete summary of my supplementary diet that
has helped me stop and reverse Alzheimer's Disease.
Amyotrophic lateral sclerosis (ALS)
This condition refers to a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement. This is a fatal, degenerative disease marked by progressive muscle weakness and atrophy.
Marijuana as ALS treatment Medical marijuana and Amyotrophic Lateral Sclerosis
Anorexia nervosa
Cannabis use can increase appetite and ease anxiety. Antispasmodic Trials show that cannabis helps relieve peripheral muscular pain and cramping.
Role of endocannabinoids and their analogues in obesity and eating disorders Brain type 1 cannabinoid receptor availability in patients with anorexia and bulimia nervosa
Appetite (See Anorexia nervosa)
One of the most fascinating aspects of cannabis in relation to appetite and eating disorders is the effect of cannabis oil on body weight.
There are over 100 different types of arthritis and studies have shown that THC and CBD have potent anti-inflammatory effects and that CBD blocks progression of rheumatoid arthritis producing significant improvement in symptoms.
Cannabis drug cuts arthritis pain What is the role of marijuana in arthritis?
Asthma
Cannabis use is shown to ease attacks in patients.
Cannabis Medical Dictionary: Asthma/
Cannabis cures asthma
Attention deficit hyperactivity disorder (ADHD)
ADHD is one of the most common psychiatric disorders of childhood and is characterized by persistent impairments in attention and concentration with the associated symptoms of impulsivity and hyperactivity.
Applying ADHD lessons to medical marijuana Medical Marijuana: No longer just for adults
Atherosclerosis (arteriosclerotic vascular disease or ASVD)
This is a condition in which an artery wall thickens as a result of the accumulation of fatty materials such as cholesterol.
Cannabis chemical 'helps heart'
Cannabinoids and Atherosclerotic Coronary Heart Disease (PDF)
Autism
In a well-documented case Marie Myung-Ok Lee has been treating her autistic son with legally acquired medical marijuana for several years. It has helped calm her son's gastrointestinal pain and decrease his associated violent behavior.
Can cannabis improve autism? NORML Backs Survey On Marijuana And Autism
Bipolar disorder
This is a psychiatric disorder characterized by extreme mood swings, ranging between episodes of acute euphoria mania and severe depression.
Burns
This burn from a car exhaust is on the patients leg.
The injury is not serious, however it is painful and prone to infection. The left side has been treated for
4 days with antibiotic cream. The right side was treated just once with cannabis oil. The patient reported pain relief and continued treatment with cannabis oil. The wound healed quickly with minimum scarring.
The injury is not serious, however it is painful and prone to infection. The left side has been treated for4 days with antibiotic cream. The right side was treated just once with cannabis oil. The patient reported pain relief and continued treatment with cannabis oil. The wound healed quickly with minimum scarring.
Achelois Fibroblast - Cannabis infused lotion for cuts and burns
A inspirational testimonial from Justin Pryor, a 3rd degree burn victim who used Achelois Fibroblast to heal his wounds with miraculous results. Visit Ibudtender.com to see where you can find Achelois Fibroblast
Cancer
Referred to medically as a malignant neoplasm, cancer is a broad group of various diseases, all involving unregulated cell growth. Cannabis oil has been shown to be extremely effectivecannabis treatment in fighting even the most aggressive of cancerous tumours.
Below are a series of images taken over a two month period where a 7mm deep melanoma (skin cancer) that was exposing the bone was successfully treated using only cannabis oil.
Scientists find cannabis compound stops metastasis in aggressive cancersCannabis treatment could stop breast cancer
Can cannabis treatment cure cancer
Information regarding the efficacy of cannabis treatment for cancer.
Scientists report that THC and other cannabinoids such as CBD (cannabidiol) slow growth and/or cause death in certain types of cancer cells growing in laboratory dishes.
Some animal studies also suggest certain cannabinoids may slow growth and reduce spread of some forms of cancer.
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