perjantai 15. kesäkuuta 2018

SOURSOP IS SAID TO CURE CANCER

SOURSOP IS SAID TO CURE CANCER!!

So based on a testimony published in the Gleaner newspaper Is The Soursop Tree
Keeping Yvonne Kirlew Alive?
 , I did some research and found some interesting bit
of information that I will share with you.


10,000 times stronger than Chemo.

The Soursop Tree – Drug Co’s Don’t want you to know




The SourSop  tree is a miraculous natural cancer cell killer, 10,000 times stronger than Chemo.

Why are we not aware of this?  It’s because some big corporation want to make back
their money spent on years of research by trying to make a synthetic version of it for
sale. Research shows that with extracts from this miraculous tree it now may be
possible 
to:
* Attack cancer safely and effectively with an all-natural therapy that   does not cause
extreme nausea,    weight loss and hair loss
* Protect your immune system and avoid deadly infections
* Feel stronger and healthier throughout the course of the treatment
* Boost your energy and improve your outlook on life
The source of this information is just as stunning: It comes from one of America ‘s
largest drug manufacturers, the fruit of over 20 laboratory tests conducted since the
1970′s! What those tests revealed was nothing short of mind numbing…

Extracts from the tree were shown to:
* Effectively target and kill malignant cells in 12 types of cancer, including colon, breast,
prostate, lung and pancreatic cancer.
* The tree compounds proved to be up to 10,000 times stronger in slowing the growth
of cancer cells than Adriamycin, a commonly used chemotherapeutic drug!
* What’s more, unlike chemotherapy, the compound extracted from the Soursop tree selectively hunts down and kills only cancer cells. It does not harm healthy cells!
The amazing anti-cancer properties of the Soursop tree have been extensively researched
– so why haven’t you heard anything about it? If Soursop extract is as half as promising
as it appears to be–why doesn’t every single oncologist at every major hospital insist on
using it on all his or her patients?
The spine-chilling answer illustrates just how easily our health–and for many, our very
lives(!)–are controlled by money and power.


Soursop–the plant that worked too well.



One of America’s biggest billion-dollar drug makers began a search for a cancer cure
and their research centered on Soursop, a legendary healing tree from the Amazon
Rainforest.

Various parts of the Soursop tree–including the bark, leaves, roots, fruit and
fruit-seeds–have been used for centuries by medicine men and native Indians in
South America to treat heart disease, asthma, liver problems and arthritis.
Going on very little documented scientific evidence, the company poured money and
resources into testing the tree’s anti-cancerous properties–and were shocked by the
results. Soursop proved itself to be a cancer-killing dynamo.


But that’s where the Soursop story nearly ended.

The company had one huge problem with the Soursop tree–it’s completely natural, and
so, under federal law, not patentable. There’s no way to make serious profits from it.
It turns out the drug company invested nearly seven years trying to
synthesize two of the Soursop tree’s most powerful anti-cancer ingredients.
If they could isolate and produce man-made clones of what makes the Soursop so
potent, they’d be able to patent it and make their money back.
Alas, they hit a brick wall. The original simply could not be replicated.
There was no way the company could protect its profits–or even make back the millions
it poured into research.

As the dream of huge profits evaporated, their testing on Soursop came to a
screeching halt. Even worse, the company shelved the entire project and chose not
to publish the findings of its research!
Luckily, however, there was one scientist from the Soursop research team whose
conscience wouldn’t let him see such atrocity committed. Risking his career, he
contacted a company that’s dedicated to harvesting medical plants from the
Amazon Rainforest and blew the whistle.


Miracle unleashed.

When researchers at the Health Sciences Institute were alerted to the news of
Soursop, they began tracking the research done on the cancer-killing tree.
Evidence of the astounding effectiveness of Soursop–and its shocking cover-up–came
in fast and furious….
….The National Cancer Institute performed the first scientific research in 1976.
The results showed that Soursop’s “leaves and stems were found effective in attacking
and destroying malignant cells.” Inexplicably, the results were published in an internal
report and never released to the public…

Since 1976, Soursop has proven to be an immensely potent cancer killer in
20 independent laboratory tests, yet no double-blind clinical trials–the typical
benchmark mainstream doctors and journals use to judge a 
treatment’s value
–were ever initiated…

A study published in the Journal of Natural Products, following a recent study conducted
at Catholic University of South Korea stated that one chemical in Soursop was
found to selectively kill colon cancer cells at  “10,000 times the potency of (the
commonly used chemotherapy drug)
Adriamycin…”

The most significant part of the Catholic University of South Korea report is that
Soursop was shown to selectively target the cancer cells, leaving healthy cells
untouched.
Unlike chemotherapy, which indiscriminately targets all actively reproducing cells
(such as stomach and hair cells), causing the often devastating side effects of nausea
and hair loss in cancer patients.

A study at Purdue University recently found that leaves from the Soursop tree killed
cancer cells among six human cell lines and were especially effective against prostate, pancreatic and lung 
cancers.



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Electron transfer chain in the inner-membrane of mitochondrion. The electron transfer chain contains five complexes designated as complex I, II, III, IV, and V (F 1 F 0 -ATP synthase). The electrochemical H + gradient provided by these membrane-bound complexes serve as energy source for ATP synthesis from ADP and inorganic phosphate by an F 1 F 0 -ATP synthase


https://www.researchgate.net/figure/Electron-transfer-chain-in-the-inner-membrane-of-mitochondrion-The-electron-transfer_fig1_232699942

The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. 
Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995

https://pubs.acs.org/doi/abs/10.1021/np980406d


Understanding mitochondrial complex I assembly in health and disease




Complex I (NADH:ubiquinone oxidoreductase) is the largest multimeric enzyme complex of the mitochondrial respiratory chain, which is responsible for electron transport and the generation of a proton gradient across the mitochondrial inner membrane to drive ATP production. Eukaryotic complex I consists of 14 conserved subunits, which are homologous to the bacterial subunits, and more than 26 accessory subunits. In mammals, complex I consists of 45 subunits, which must be assembled correctly to form the properly functioning mature complex. Complex I dysfunction is the most common oxidative phosphorylation (OXPHOS) disorder in humans and defects in the complex I assembly process are often observed.

The Warburg hypothesis, sometimes known as the Warburg theory of cancer,
postulates that the driver of tumorigenesis is an insufficient cellular respiration caused by 
insult to mitochondria.[1] The term Warburg effect describes the observation that

cancer cells, and many cells grown in-vitro, exhibit glucose fermentation even when
enough 
oxygen is present to properly respire. In other words, instead of fully respiring
in the presence of adequate oxygen,
cancer cells ferment.

He hypothesized that cancer, malignant growth, and tumor growth are caused by the
fact that 
tumor cells mainly generate energy (as e.g., adenosine triphosphate / ATP)
by non-oxidative breakdown of 
glucose (a process called glycolysis).
This is in contrast to "healthy" cells which mainly generate energy from oxidative
breakdown of 
pyruvate.
Pyruvate is an end-product of 
glycolysis, and is oxidized within the mitochondria
.





4.2. Annonaceous Acetogenins

AGEs are a unique class of C-35/C37 secondary metabolites derived from long chain
(C-32/C34) fatty acids in the polyketide pathway. They are usually characterized by a
combination of fatty acids with a 2-propanol unit at C-2 that forms a methyl-substituted
α,β-unsaturated γ-lactone [72]. Since the discovery of uvaricin from Uvaria accuminata
in 1982, more than 500 AGEs have been identified from different parts of the plants in the
Annonaceae family [73,74]. Due to the special structures and extensive biological activities,

AGEs have attracted significant scientific interest in recent years.

Various biological activities have been reported for AGEs, including antimalarial,
antiparasitic and pesticidal activities
[,].
However, the biological activities of AGEs are primarily characterized with toxicity
against cancer cells and inhibitory effects against the mitochondrial complex I
(mitochondrial NADH: ubiquinone oxidoreductase)
[,].
Phytochemical investigations and biological studies on different parts of the A. muricata plant resulted in the identification of a wide array of AGE compounds, as summarized in Table 1.
The chemical structures of the major acetogenins are shown in Figure 2.
To the best of our knowledge, at the time of preparation (January 2015) of the present
review over 100 AGEs have been identified in A. muricata.

http://graviolateam.blogspot.com/2014/08/best-ways-to-prepare-soursop-leaves-to.html

Electron Transport Chain | 8.12.2016

The Electron Transport Chain & complexes I-IV that pump protons out of the
Mitochondria by the transfer of the electrons carried on NADH & FADH2 to maintain
the concentration gradient of the protons "high in the intermembrane space &
low in the matrix of the Mitochondria"



Characterization of the Annonaceous acetogenin, annonacinone, a natural product
inhibitor of plasminogen activator inhibitor-1
(Scientific Reports volume 6, Article number: 36462 (2016) doi:10.1038/srep36462)

In this study, we evaluated a novel PAI-1 inhibitor, annonacinone, a natural product from
the Annonaceous acetogenins group
- High plasma levels of PAI-1 are related to the development of thrombosis as well as
several other pathologies such as cardiovascular diseases and metabolic disturbances
1,2,3.
- Moreover PAI-1 is able to promote tumor angiogenesis and high PAI-1 level in solid
tumors are associated with a poor prognosis 4,5.


Discussion
In conclusion, our work showed that, as well as their other biological properties,
natural Annonaceous acetogenins, and particularly annonacinone, have an effect on
fibrinolysis.
Indeed, annonacinone is a potent inhibitor of PAI-1 in vitro, ex vivo and in vivo.
Annonacinone mechanism of action and binding site on PAI-1 were also enlightened.
Altogether, annonacinone appears to be a very promising antithrombotic agent and should
be further studied.

https://www.nature.com/articles/srep36462

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Graviola -hedelmän ja -lehtien aineosat, annonaceus acetogenins, etsivät nopeasti kasvavat, paljon energiaa tuhlaavat syöpäsolut ja estävät niiden ravinnon
ja hapen saannin.

- Graviolan aineosat pysäyttävät syöpäsolujen kasvun jo niiden energian-
tuotannossa
, mitokondrioissa, Complex 1: n elektronisiirto -ketjussa.
Electron transport chain COMPLEX 1 (NADH ubiquinone oxidoreductase)




Elektroninsiirtoketju



I entsyymi on NADH-dehydrogenaasi, II on sukkinaattidehydrogenaasi, III on sytokromi b-ckompleksi ja IV entsyymi on sytokromi-c-oksidaasi

Elektroninsiirtoketju on mitokondrion sisäkalvolla (eukaryootit) tai solukalvon kalvoproteiineissa (bakteerit) tapahtuva energiaa tuottava reaktiosarja,jossa sitruunahappokierrossa ja sitä edeltäneissä reaktioissa koentsyymeille NADH ja FADHsiirtyneitä elektroneja siirrellään elektroninsiirtoketjun entsyymiltä toiselle, jolloin elektronit menettävät potentiaalienergiaansa vähitellen, vapauttaen samalla energiaa.Vapautuvan energian avulla mitokondrion matriksista pumpataan protoneja mitokondrion kalvojen välitilaan, mikä aiheuttaa elektrokemiallisen gradientin eli potentiaali- ja protonikonsentraatioeron matriksin ja välitilan välille. Muodostunut gradientti purkautuu ATP-syntaasientsyymin kautta, jolloin muodostuu suurenergiaista fosfaattiyhdistettä, ATP:tä.
https://fi.wikipedia.org/wiki/Elektroninsiirtoketju

____


Fibrinolysis is a process that prevents blood clots from growing and becoming 
problematic.[1]
The fibrinolytic system is closely linked to control of inflammation,
and plays a role in disease states associated with inflammation.Plasmin is produced in
an inactive form, plasminogen, in the liver.
PAI-1 is present in increased levels in various disease states, such as a number of
forms of cancer, as well as in obesity and the metabolic syndrome. It has been linked
to the increased occurrence of thrombosis in patients with these conditions.


Figure 5: Depiction of a putative binding mode of annonacinone against the active form of PAI-1

The serpin mechanism

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Chemical structures of the major compounds isolated from Annona muricata.
Published online 2015 Jul 10. doi:  10.3390/ijms160715625

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